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MEDICAL STUDIES ABOUT ARTICHOKE EXTRACT & ENZYMES
Study 1

"Artichoke Leaf Extract May Provide Irritable Bowel Syndrome Relief" A DG Review

"Artichoke leaf extract reduces symptoms of irritable bowel syndrome in a post-marketing surveillance study"

This extract is used for dyspepsia, which shares symptoms with IBS and Crohns Disease. As a result, the researchers decided to examine whether the extract would also provide IBS symptom relief.

They studied a sub-group of dyspeptic syndrome patients who were already being monitored in a six-week, post-market surveillance study of artichoke leaf extract. These sub-group participants also had IBS symptoms.

Investigators report that the IBS patients had significant reductions in the severity of their IBS symptoms. They also note that both patients and their doctors gave favourable evaluation of the overall effectiveness of the extract.

"Furthermore, 96 percent of patients rated artichoke leaf extract as better than or equal to previous therapies administered for their symptoms."(8)

Study 2

Germany's Commission E has authorized the use
of Artichoke extract for "dyspeptic problems."(3)    
Dyspepsia is a "catch all" term that indicates a 
variety of digestive problems including discomfort
in the stomach, bloating, lack of appetite, Nausea,
and Diarrhea or Constipation, even Crohns disease.

In Europe, dyspepsia is commonly attributed to inadequate flow of bile, which is why artichoke leaf is used as a treatment for this condition. Evidence tells us that artichoke leaf does indeed stimulate the bile flow.(4),(5),(6)

Study 3

A clinical study showed an improvement of symptoms in 50% of patients with dyspeptic syndrome after 14 days of treatment with artichoke leaf extract. The study involved 60 patients with non-specific symptoms such as upper abdominal pain, heartburn, bloating, constipation, diarrhea, nausea, vomiting and Crohns. (Kupke et al., 1991) (1)

Study 4

Interesting results were also demonstrated in a large open label study of 417 participants with liver or bile duct disease. Most of these patients had had longstanding symptoms, some of them for many years. They suffered from upper abdominal pain, bloating, constipation, lack of appetite and nausea. These patients were treated with artichoke leaf extract for four weeks. After one week around 70% of the patients experienced improvement of their symptoms, and after four weeks the percentage was even higher (approx. 85%). (Held 1991) (2)

Study 5

Even more remarkable improvement was shown in another recently completed open label study (Fintelmann, 1996), where 553 outpatients with non-specific dyspeptic complaints were treated with a standardized artichoke leaf extract. The subjective complaints declined significantly within 6 weeks of treatment. Improvements were found for vomiting (88%), nausea (83%), abdominal pain (76%), loss of appetite (72%), severe constipation (71%), flatulence (68%) and fat intolerance (59%). Ninety-eight percent of the patients judged the effect of the extract to be considerably better, somewhat better or equal to that achieved during previous treatment with other drugs. (7)

WARNING: Those with gall stones or